Second seed Lleyton Hewitt was luckier as the Australian's opponent, Chile's Nicolas Massu was forced out of their match after seven games with a hip injury.

Russia's Marat Safin, winner in 2000 and 2002, eased past Austrian Juergen Melzer 6-2, 7-5 and will meet Hewitt in the last eight.

Former world number one Roddick was outserved and outpaced by qualifier Max Mirnyi of Belarus 7-6, 6-2 in just 65 minutes.

The American, who had been out of action for a month after the US Open, looked out of steam against an opponent who beat him at his own game.

The tiebreak, which the towering Mirnyi, dubbed the Beast, won 7-2, set the tone for a one-sided second set.

Hitting aces and service winners, the Belarussian never let the hapless Roddick back into the match.

Holder Henman, beaten 7-5, 6-1 by another in-form player, Russian Mikhail Youzhny, made it clear he had turned his sights towards the Masters Cup.

"To be honest, the goal was to qualify for Houston. It's been a while since I have been in the world championships if you like," said the Briton, who played in the season-ending tournament in 1997 and 1998 before it became the Masters Cup.

The third-seeded Briton had made Paris almost his second home in the last year, winning the most lucrative of the Masters Series tournaments in Bercy a year ago before reaching the French Open semifinals in June.