He is also unlikely to play any part in the remainder of the current English season with his county, Essex, after being advised to rest from bowling for six weeks -- a move which could scupper his hopes of appearing in October's ICC Champions Trophy one-day tournament in India.

Gough's place in the England party for the remainder of the Pakistan series will be taken by Durham opening bowler Graham Onions.

The 35-year-old Gough, England's most successful one-day bowler with 235 wickets, was recalled to international cricket for Monday's Twenty20 match against Pakistan, after a year on the sidelines.

He then featured in Wednesday's washed out one-day series opener and Pakistan's seven-wicket win at Lord's on Saturday, where his eight wicketless overs cost 44 runs.

ECB chief medical officer, Dr Peter Gregory, said: "An MRI scan today (Sunday) showed a marked bone stress reaction in his fibula and Darren has been advised to rest from bowling for six weeks. He will return to Essex to receive ongoing assessment and rehabilitation."