The labor union federation PIT-CNT and other groups organized the march, in Uruguay, Bush's second stop on a five-country goodwill tour meant to support democracy and foster trade.

Marchers waved posters with Bush's image, his mouth stained with blood, and the word "Killer" and "Yes to Mercosur, no to Imperialism," before some used stones and branches to smash the McDonald's windows.

Mercosur is the regional common market of South America to which Uruguay belongs.

The restaurant that was attacked is just blocks from the hotel Bush where will be lodged in Montevideo.

US-based McDonald's has become a symbol of globalization, though it usually stresses local branches have local franchise owners.

Two journalists were injured covering the demonstrations, authorities said.