Victory would give Inter an unbeatable 19-point advantage on Roma, assuring the champions their 14th Serie A crown with six games left this season.

The tie between the top two sides was first scheduled back in February, but was postponed following the riots in Sicily.

Inter, who finished third last season but were awarded the title after Juventus and AC Milan were found guilty of match-fixing, will be looking to make the most of their home advantage for the celebrations as well as maintaining their unbeaten run this season.

A victory would also allow Inter to focus on their bid to break the 100-point barrier. To do so they need 19 points from the remaining 21 on offer.

Inter have currently 81 points from 31 games, with AS Roma on 65.

But Roma will be gunning to cause some upsets in Milan, a week after being humiliated 7-1 by Manchester United in the Champions League.

"We're not going to the San Siro to join in their party," warned captain Francesco Totti.

"It's an important match for them, but for us as well -- we don't want to let our grip on second place slip away."

After a comfortable 4-0 win at Sampdoria on Sunday, Roma demonstrated that they had recovered from their Old Trafford mauling.

By contrast Inter were almost unrecognisable as they were held to a 2-2 draw at home to Palermo, a week after a goalless draw against relegation-threatened Reggina.

It was the first time this season that the leaders have had to settle for two consecutive draws.

"We gave them too much space and didn't start the match with enough aggression and focus. I hope that that won't happen against Roma," said coach Roberto Mancini.

Mancini has however several players sidelined with injuries including defender Maxwell and midfielder Patrick Vieira, with striker Hernan Crespo uncertain after picking up a thigh injury against Palermo.

On Roma's side Brazilian midfielder Rodrigo Taddei is uncertain.

Elsewhere Wednesday, third-placed Lazio, nine points behind Roma, host Chievo, while AC Milan will be looking to secure the fourth qualifying spot for Champions League next season when they visit tailenders Ascoli.